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Crystals were not investigated scientifically until the 17th century, when Johannes Kepler hypothesized (1611) that the hexagonal symmmetry of snowflake crystals was due to a regular packing of spherical water particles.
 

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Saturday, 06 October 2007

Arnold lab


Research Overview 

Drs. Eddy and Gail Ferstandig Arnold and their colleagues are working to develop and apply structure-based drug and vaccine designs for the treatment and prevention of serious human diseases. In pursuit of these goals, their laboratory takes advantage of cutting-edge research tools, including X-ray crystallography, molecular biology, virology, protein biochemistry, and macromolecular engineering.

The approaches being developed in the Arnold laboratory are broadly applicable to a wide array of human health problems, ranging from infectious diseases to cancer and diseases caused by hereditary genetic defects. Much of the Arnold lab’s research effort to date has focused on the development of drugs and vaccines for the treatment of AIDS. Examples of the results of these studies include: 1) collaborative development of potential drugs for the treatment of AIDS, some of which may be more effective than treatments in current use; and 2) production of AIDS vaccine candidates that have elicited protective immune responses against HIV.


 

 


 

Last Updated ( Thursday, 22 May 2008 )
 

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Research Highlights

  • High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations. link

  • HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. link 

  • Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097. link

  • Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains. link

  • Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability. link

  • Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. link

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